IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression
نویسندگان
چکیده
منابع مشابه
Acute Myeloid Leukemic Cells Express NKG2D or Shed off NKG2D Ligand to Escape Immune-Surveillance
Submit Manuscript | http://medcraveonline.com that, they are capable of escaping the immune-surveillance [1]. Escaping immune-surveillance can result in serious ailment or even death, and in such instance, the immune system is said to have been compromised. In this editorial, the spotlight is put on one of such cancers, acute myeloid leukemia (AML), which has demonstrated its ability to evade i...
متن کاملNatural Killer Cell Cytotoxicity Against SKOV3 after HLA-G Downregulation by shRNA
Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: The expression level of HLA-G was measured by real-time PCR and flowcytometry after transfec...
متن کاملMechanisms of Tumor and Viral Immune Escape from Natural Killer Cell-Mediated Surveillance
Human natural killer (NK) cells recognize and efficiently eliminate MHC class I low or negative malignant targets and virally infected host cells, without requirement for prior sensitization. However, viruses and various tumor cells display elaborate adaptations to evade and overcome immunosurveillance. The current review focuses on escape mechanisms of viruses and malignantly transformed ‘stre...
متن کاملMechanisms of Tumor and Viral Immune Escape from Natural Killer Cell-Mediated Surveillance
Human natural killer (NK) cells recognize and efficiently eliminate MHC class I low or negative malignant targets and virally infected host cells, without requirement for prior sensitization. However, viruses and various tumor cells display elaborate adaptations to evade and overcome immunosurveillance. The current review focuses on escape mechanisms of viruses and malignantly transformed ‘stre...
متن کاملMechanisms of tumor and viral immune escape from natural killer cell-mediated surveillance.
Human natural killer (NK) cells recognize and efficiently eliminate MHC class I low or negative malignant targets and virally infected host cells, without requirement for prior sensitization. However, viruses and various tumor cells display elaborate adaptations to evade and overcome immunosurveillance. The current review focuses on escape mechanisms of viruses and malignantly transformed 'stre...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2016
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/now061